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Various Articles on PR


HLA antigens in palindromic rheumatism and palindromic onset rheumatoid arthritis.

Fisher LR, Kirk A, Awad J, Festenstein H, Alonso A, Perry JD, Shipley M.

Fifty patients who presented with typical palindromic rheumatism of at least 6 months' duration were tissue-typed for HLA A, B, C antigens. DR typing was also performed but was not possible for technical reasons in three patients. Twenty-three patients who had progressed to definite or classical rheumatoid arthritis (RA) after a mean interval of 5 years were compared with 20 patients whose palindromic attacks had persisted over a similar period. Both groups showed a significantly higher frequency of DR4 antigen than a control population. The RA group also showed an increased frequency of DR1. There was no significant difference in the frequency of DR4 or any other DR antigen between the two patient groups. The frequency of B27 antigen was significantly higher in the palindromic group compared with the controls. It is suggested that although DR4 may be associated with a tendency to inflammatory joint problems, environmental or other unrelated genetic factors may be more important in determining the progression of palindromic rheumatism to RA.

PMID: 3490893 [PubMed - indexed for MEDLINE]

Antiphospholipid syndrome and palindromic rheumatism: a new possible association.

Reitblat T, Litinsky I, Caspi D, Elkayam O.

Rheumatology Outpatient Clinics, Barzilai Medical Centre, 3 Histadrut St., Ashkelon, and Sourasky Medical Centre, Tel Aviv University, Israel. alex@barzi.health.gov.il

OBJECTIVE: The aim of this study was to report six patients with palindromic rheumatism (PR) in whom signs, symptoms, and/or serologic evidence of antiphospholipid syndrome (APS) developed. METHODS: The medical histories of the patients were reviewed with special emphasis on age, gender, duration of PR, and lapse of time until antiphospholipid antibodies were detected or APS was diagnosed. Three representative cases are described. RESULTS: Two patients were women and four were men. Their mean age was 49.3 years (range 36-80), and the mean duration of PR was 5.5 years (range 3-8). In all patients, raised titers of antiphospholipid antibodies were found on two or more occasions. Two patients developed clinical pictures compatible with APS, two showed symptoms which may be attributable for APS, and raised titers of antiphospholipid antibodies were found in only two. CONCLUSION: It seems that the appearance of these two uncommon conditions together is more than coincidental and may point to a previously unreported clinical association.

PMID: 16189657 [PubMed - indexed for MEDLINE]

A link below to more PR articles on PubMed